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Amnestic syndrome symptoms1/4/2024 ![]() ![]() Reported that donepezil does not seem to provide marked beneficial effect in patient with Korsakoff’s syndrome, their study had only 7 subjects and relatively short follow up period. No side effects were observed during treatment of donepezil.ĭiscussion: In the literature, there are several cases and a small study about usage of donepezil in Korsakoff’ssyndrome. ![]() His relatives said that there is significant improvement in patient’s symptoms such as orientation, confabulation and memory, at that time, MMSE was 25. The patient was followed up 3 months after discharge. Total time of hospitilitation was 50 days. Six weeks later, confabulation, disorientation and memory impairment showed moderate improvement and SMMT was 21. Minimal improvement in clinical status of the patient was observed within 3 weeks following donapezil initiation. After 1 weeks donepezil dosage increased 10 mg/day. Because of no clinical improvement during first week, donepezil 5 mg/day treatment was started additionally. Treatment of patient was started as thiamine 100 mg/day, quetiapine 100 mg/day and levotiron 50 mg/day. The point of the standardized mini-mental test (SMMT) was 18. Serum level of GGT 103 U/L, total protein, 5 g/dl, albumin 2.6 g/dl, fT4 0.59 ng/dl, other biochemistrical and hematological values were normal. In magnetic resonance imaging, there was sulcus expansion and atrophy of the mammillary bodies. After examination and clinical interview, the patient was diagnosed Alcohol-induced persisting amnestic syndrome according to DSM-IV(Diagnostic and statically manual of mental disorders IV edition) diagnostic criteria. It was found, nystagmus, hypoesthesia on right lower extremity, ataxia in neurological examination. On his mental examination there was decreased self-care, corrupted orientation, impaired close memory, confabulation, retrograde and anterograde amnesia, labile affect, psychomotor restlessness, insufficient insight. The patient had a history of alcohol use since nearly 30 years, separated from her wife six years ago. In this report, a case has been reported about effect of donepezil in Korsakoff syndrome is presented.Ĭase report: A 51-year-old male patient was admitted to psychiatry outpatient clinic of Necmettin Erbakan University Meram Medical Faculty with insomnia, disable to eat, a strange speech, forgetfulness, difficulty in recognize his relatives for a month. There is not enough information about its treatment. Introduction: Alcohol-induced persisting amnestic disorder (Korsakoff’s syndrome) is generally defined as an irreversible and important clinical condition. ![]()
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